Discovered in the United States over 100 years ago, sickle cell disease (SCD) statistics are staggering. In the US, one in 2,500 newborn babies has the disease and approximately 54,000 babies are born each year with sickle cell trait. There are approximately 80,000 Americans with sickle cell disease and 3.5 million with sickle cell trait and related disorders. Sickle Cell Anemia (SCA) is an inherited and lifelong condition. While there is no generally applicable cure for SCD, several promising developments have occurred to improve the quality of life and survival of SCD patients. The K.I.S. Foundation also provides financial support to research institutions in the quest to find a universal cure for SCD.